#ATGSeminar

Theme: Endometriosis & Fertility!

#AtgEndometriosis

Topic: Notes on Endometriosis ( Intro, Causes, Risk factors and Symptoms )

Introduction

This is an often very painful disorder in which tissue that normally lines the inside of your (womb) called the endometrium grows outside your womb instead. This condition can involve any pelvic organs, but most commonly involves your ovaries, fallopian tubes and the tissue lining your pelvis. Rarely, it may also spread beyond pelvic organs.

With endometriosis, displaced endometrial tissue continues to act as it normally would (it thickens, breaks down and bleeds with each menstrual cycle). Because this displaced tissue has no way to leave your body, it becomes trapped thus leading to painful symptoms. When endometriosis involves the ovaries, cysts called endometriomas may form. Surrounding tissue can become irritated, eventually developing scar tissue and adhesions — abnormal bands of fibrous tissue that can cause pelvic tissues and organs to stick to each other. This is a very painful condition. Endometriosis can cause pain, sometimes severe especially during your period. Fertility problems also may develop. Fortunately, effective treatments are available.

Endometriosis is sometimes mistaken for other conditions that can cause pelvic pain, such as pelvic inflammatory disease (PID) or ovarian cysts. It may be confused with irritable bowel syndrome (IBS), a condition that causes bouts of diarrhea, constipation and abdominal cramping. IBS can accompany endometriosis, which can complicate the diagnosis.

Causes

The exact cause of endometriosis is not certain, however there are possible explanations which include:

1● Retrograde menstruation. This happens, when menstrual blood containing endometrial cells flows back through the fallopian tubes and into the pelvic cavity instead of out of the body. These displaced endometrial cells stick to the pelvic walls and surfaces of pelvic organs, where they grow and continue to thicken and bleed over the course of each menstrual cycle.

2● Transformation of peritoneal cells. In what’s known as the “induction theory,” experts propose that hormones or immune factors promote transformation of peritoneal cells, cells that line the inner side of your abdomen into endometrial cells.

3● Embryonic cell transformation. Hormones such as estrogen may transform embryonic cells — cells in the earliest stages of development — into endometrial cell implants during puberty.

4● Surgical scar implantation. After a surgery, such as a hysterectomy or C-section, endometrial cells may attach to a surgical incision.

5● Endometrial cells transport. The blood vessels or tissue fluid (lymphatic) system may transport endometrial cells to other parts of the body.

6● Immune system disorder. It’s possible that a problem with the immune system may make the body unable to recognize and destroy endometrial tissue that’s growing outside the uterus

Risk factors

Several factors place you at greater risk of developing endometriosis, such as:

♤ Never giving birth

♤ Starting your period at an early age

♤ Going through menopause at an older age

♤ Short menstrual cycles — for instance, less than 27 days

♤ Having higher levels of estrogen in your body or a greater lifetime exposure to estrogen your body produces

♤ Low body mass index ( BMI)

♤ Alcohol consumption

♤ One or more relatives (mother, aunt or sister) with endometriosis

♤ Any medical condition that prevents the normal passage of menstrual flow out of the body

♤ Uterine abnormalities

Endometriosis usually develops several years after the onset of menstruation (menarche). Signs and symptoms of endometriosis end temporarily with pregnancy and end permanently with menopause, unless you’re taking estrogen.

People may experience (Symptoms):

♧ The most common symptom is severe pelvic pains in the lower abdomen, lower back, pelvis, rectum, or vagina

♧ Pain circumstances: can occur during sexual intercourse or while defecating.

♧ Also, although many women experience cramping during their menstrual period, women with endometriosis typically describe menstrual pain that’s far worse than usual

♧ Menstrual: heavy menstruation, irregular menstruation, painful menstruation, or spotting

♧ Gastrointestinal: constipation or nausea

♧ Abdominal: abdominal fullness or cramping

♧ Infertility: Endometriosis is first diagnosed in some women who are seeking treatment for infertility.

Thank you

Chuk Ufondu. MBBS, MPH , CPH

Reference & Photo Credit

◇ Mayo Clinics

◇ Www.draxe.com

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